A Multifunction Telecommunications Channel Break Switch

The Cypress Multifunction Packet Switch

CFTR: break a pump, make a channel.

R arely do the two broad motivations propelling molecular biological research—discovery of intricate molecular mechanisms and understanding the underlying causes of human disease—converge in a single system. An example of such convergence is provided by cystic fibrosis (CF), an all-toocommon genetic disease characterized by devastating chronic lung infection in children and young adults (1). Th...

Assessing the Consequences of a Channel Switch

S marketing channels is an expensive and sticky decision. While a number of theories suggest efficiency and strategic differences between channels, there is virtually no work on combining these ideas into an empirically workable methodology to assess the impact of a channel switch. In this study, we undertake to close this gap with an empirical study of the sports drink market, featuring compet...

Phosphorylation: The Molecular Switch of Double-Strand Break Repair

Repair of double-stranded breaks (DSBs) is vital to maintaining genomic stability. In mammalian cells, DSBs are resolved in one of the following complex repair pathways: nonhomologous end-joining (NHEJ), homologous recombination (HR), or the inclusive DNA damage response (DDR). These repair pathways rely on factors that utilize reversible phosphorylation of proteins as molecular switches to reg...

Channel Estimation and Interpolation for Fourth Generation Mobile Broadband Telecommunications

This paper studies the problem of channel estimation for the downlink in broadband LTE communications. A Kalman Filter is used to combine channel soundings made with pilot tones that are deployed at different times and in different frequency bands on a pre-selected pattern. This Kalman filter is presented in a form directly suitable for implementation as a periodically time varying filter, in t...